CURRENT RESEARCH INTERESTS:  

Molecular mechanisms of the immune response. Mechanisms of antigenic peptide selection for presentation by MHC I molecules (more).

 


Antigenic peptide trimming by ER amipopeptidases (more).

 




Elaboration of protein structure-function by biophysical methods (more).

 

Role of Apolipoprotein E in cholesterol homeostasis (more). 

 

 


RECENT PUBLICATIONS:

 Irini Evnouchidou, Frank Momburg, Athanasios Papakyriakou, Angeliki Chroni, Leondios Leondiadis, Shih-Chung Chang, Alfred L. Goldberg and Efstratios Stratikos. The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS ONE  (2008), 3(11),e3658.

Angeliki Chroni, Serapion Pyrpassopoulos, Angelos Thanassoulas, George Nounesis, Vassilis I. Zannis and Efstratios Stratikos. Biophysical Analysis of Progressive C-Terminal Truncations of Human Apolipoprotein E4: Insights into Secondary Structure and Unfolding Properties. Biochemistry (2008), 47, 9071–9080.
Dimitra Georgiadou and Efstratios Stratikos. Cellular mechanisms that edit the immunopeptidome and modulate the immune response. Current Proteomics, 2009, v.6 (1).


GRADUATE STUDENTS:

Irini Evnouchidou, M.S.

Dimitra Georgiadou, B.S. 


PAST RESEARCH INTERESTS:

 Molecular mechanism of protease inhibition by Serpins (Serine Protease Inhibitors). Structure of the Serpin-Protease covalent intermediate (more).

 


Mechanisms of antigenic peptide selection for presentation by MHC II molecules. Catalysis of antigenic peptide exchange by HLA-DM (more).

 

 


MAJOR TECHNIQUES USED IN THE LAB:


Recombinant protein expression and purification (more)

 

 

 Enzymology: enzyme kinetics, substrate specificity (more)

 

 

Structural biology: X-ray crystallography & Molecular modeling (more)

 

 

 Biophysics: investigation of structure-function relationship of proteins (more)